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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-1-18
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pubmed:abstractText |
Classic hereditary hemochromatosis is an autosomal recessive iron-overload disorder associated with mutation of the HFE gene. The homozygous genetic defect predisposes to a chain of events that may culminate in severe damage in multiple organs. Pathologic implications of heterozygous defect are still questionable; in fact since these individuals may have slight increases in intra-cellular iron, it has been questioned whether this would enhance damage from other diseases. We investigated whether steatohepatitis and chronic hepatitis C can be worsened by heterozygosis for C282Y and H63D.
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pubmed:language |
ita
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0009-9074
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17228846-Biopsy,
pubmed-meshheading:17228846-Data Interpretation, Statistical,
pubmed-meshheading:17228846-Fatty Liver,
pubmed-meshheading:17228846-Ferritins,
pubmed-meshheading:17228846-Hemochromatosis,
pubmed-meshheading:17228846-Hepatitis C, Chronic,
pubmed-meshheading:17228846-Heterozygote,
pubmed-meshheading:17228846-Histocompatibility Antigens Class I,
pubmed-meshheading:17228846-Humans,
pubmed-meshheading:17228846-Liver,
pubmed-meshheading:17228846-Membrane Proteins,
pubmed-meshheading:17228846-Mutation,
pubmed-meshheading:17228846-Transferrin
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pubmed:articleTitle |
[Heterozygosis H63D in patients with steatohepatitis and chronic hepatitis C].
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pubmed:affiliation |
Dipartimento di Medicina Interna e Patologie Sistemiche, Università di Catania, U.O. di Medicina Interna Azienda Policlinico. d.pulvirenti2@virgilio.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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