Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-17
pubmed:abstractText
Na(+),K(+) ATPase is an essential ion pump involved in regulating ionic concentrations within epithelial cells. The zebrafish heart and mind (had) mutation, which disrupts the alpha1B1 subunit of Na(+),K(+) ATPase, causes heart tube elongation defects and other developmental abnormalities that are reminiscent of several epithelial cell polarity mutants, including nagie oko (nok). We demonstrate genetic interactions between had and nok in maintaining Zonula occludens-1 (ZO-1)-positive junction belts within myocardial cells. Functional tests and pharmacological inhibition experiments demonstrate that Na(+),K(+) ATPase activity is positively regulated via an N-terminal phosphorylation site that is necessary for correct heart morphogenesis to occur, and that maintenance of ZO-1 junction belts requires ion pump activity. These findings suggest that the correct ionic balance of myocardial cells is essential for the maintenance of epithelial integrity during heart morphogenesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-10428461, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-10491254, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-10942705, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-10963432, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-11179415, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-11257119, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-11591315, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-11591316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-11739775, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12545177, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12570983, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12782686, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12900452, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12930776, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-12950077, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-14602677, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-15030760, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-15140881, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-15297381, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-15788456, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-16319113, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-16525119, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-1662394, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-16638803, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-2154258, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-2176238, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-8484714, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-8589427, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-8636221, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-9012502, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-9374629, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-9405869, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-9535860, http://linkedlifedata.com/resource/pubmed/commentcorrection/17227894-9815123
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ouabain, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase, http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins, http://linkedlifedata.com/resource/pubmed/chemical/atp1a1b protein, zebrafish, http://linkedlifedata.com/resource/pubmed/chemical/mpp5 protein, zebrafish, http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C lambda, http://linkedlifedata.com/resource/pubmed/chemical/zonula occludens-1 protein
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-30
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:17227894-Amino Acid Sequence, pubmed-meshheading:17227894-Animals, pubmed-meshheading:17227894-Cell Membrane, pubmed-meshheading:17227894-Cell Polarity, pubmed-meshheading:17227894-Cytoplasm, pubmed-meshheading:17227894-Embryo, Nonmammalian, pubmed-meshheading:17227894-Guanylate Cyclase, pubmed-meshheading:17227894-Heart, pubmed-meshheading:17227894-Intercellular Junctions, pubmed-meshheading:17227894-Isoenzymes, pubmed-meshheading:17227894-Membrane Proteins, pubmed-meshheading:17227894-Models, Biological, pubmed-meshheading:17227894-Molecular Sequence Data, pubmed-meshheading:17227894-Morphogenesis, pubmed-meshheading:17227894-Mutation, pubmed-meshheading:17227894-Myocardium, pubmed-meshheading:17227894-Ouabain, pubmed-meshheading:17227894-Phosphoproteins, pubmed-meshheading:17227894-Phosphorylation, pubmed-meshheading:17227894-Protein Kinase C, pubmed-meshheading:17227894-Sequence Homology, Amino Acid, pubmed-meshheading:17227894-Sodium-Potassium-Exchanging ATPase, pubmed-meshheading:17227894-Transfection, pubmed-meshheading:17227894-Zebrafish, pubmed-meshheading:17227894-Zebrafish Proteins
pubmed:year
2007
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