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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-17
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pubmed:abstractText |
We recently postulated that constitutive activation of Ataxia Telangiectasia, Mutated (CAA) and constitutive histone H2AX phosphorylation (CHP) seen in cells not treated with genotoxic agents are the events triggered by DNA damage caused by endogenous reactive oxygen species (ROS), the product of mitochondrial oxidative metabolism. The aim of this study was to seek further evidence in support of this postulate, namely to test whether the levels of CAA and CHP correlate with cells metabolic activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-7722
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-13
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:17227291-Aged,
pubmed-meshheading:17227291-Cell Cycle Proteins,
pubmed-meshheading:17227291-Cells, Cultured,
pubmed-meshheading:17227291-DNA,
pubmed-meshheading:17227291-DNA-Binding Proteins,
pubmed-meshheading:17227291-Histones,
pubmed-meshheading:17227291-Humans,
pubmed-meshheading:17227291-Lymphocyte Activation,
pubmed-meshheading:17227291-Male,
pubmed-meshheading:17227291-Middle Aged,
pubmed-meshheading:17227291-Models, Biological,
pubmed-meshheading:17227291-Phosphorylation,
pubmed-meshheading:17227291-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17227291-RNA,
pubmed-meshheading:17227291-Tumor Suppressor Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
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pubmed:affiliation |
Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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