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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-4-2
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pubmed:abstractText |
There is evidence that cancer is immunogenic under certain situations. IL-2 is described to stimulate an effective antitumor immune response in vitro and in vivo. The ability of cancer patients to undergo surgical resection is still the most important prognostic factor for many solid tumors, including gastric adenocarcinoma. The host immune system may be further compromised by surgical procedures leading to a generalized state of immunodepression in the post-operative period. The aim of this randomized case-control study is to evaluate the effects of pre-operative low-dose IL-2 treatment on patients with gastric adenocarcinoma who undergo surgery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1068-9265
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pubmed:author |
pubmed-author:AlettiGiacomoG,
pubmed-author:BovoGiorgioG,
pubmed-author:BrennaAmbrogioA,
pubmed-author:CaprottiRobertoR,
pubmed-author:CesanaGiovanni CarloGC,
pubmed-author:KaufmanHowardH,
pubmed-author:PiacentiniGaiaG,
pubmed-author:RomanoFabrizioF,
pubmed-author:ScottiMarcoM,
pubmed-author:UggeriFrancoF,
pubmed-author:VaghiMassimoM
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1295-304
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pubmed:meshHeading |
pubmed-meshheading:17225981-Adenocarcinoma,
pubmed-meshheading:17225981-Aged,
pubmed-meshheading:17225981-Antineoplastic Agents,
pubmed-meshheading:17225981-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17225981-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17225981-Case-Control Studies,
pubmed-meshheading:17225981-Female,
pubmed-meshheading:17225981-Humans,
pubmed-meshheading:17225981-Immunotherapy,
pubmed-meshheading:17225981-Interleukin-2,
pubmed-meshheading:17225981-Killer Cells, Natural,
pubmed-meshheading:17225981-Lymphocyte Activation,
pubmed-meshheading:17225981-Lymphocyte Count,
pubmed-meshheading:17225981-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:17225981-Male,
pubmed-meshheading:17225981-Neoadjuvant Therapy,
pubmed-meshheading:17225981-Preoperative Care,
pubmed-meshheading:17225981-Prognosis,
pubmed-meshheading:17225981-Stomach Neoplasms,
pubmed-meshheading:17225981-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
Low-dose interleukin-2 administered pre-operatively to patients with gastric cancer activates peripheral and peritumoral lymphocytes but does not affect prognosis.
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pubmed:affiliation |
Department of General Surgery, University of Milano-Bicocca, S. Gerardo Hospital, via Donizzetti 106, Monza, 20052 Milan, Italy. giovanni.cesana@gmail.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial
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