The heterogeneity of clinical findings in studies evaluating the efficacy of naltrexone in the treatment of alcohol dependence has led to growing efforts to explore novel approaches to data analysis. The objective of this study was to identify distinct trajectories of daily drinking over time in two negative clinical trials and to determine whether naltrexone affected the probability to follow a particular trajectory.
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut, USA. ralitza.gueorguieva@yale.edu <ralitza.gueorguieva@yale.edu>
