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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
Nerve growth factor (NGF) is an important substance in the skin, where it modulates nerve maintenance and repair. However, the direct link between NGF and pruritic diseases such as atopic dermatitis is not yet fully understood. Our previous study showed that NGF plays an important role in the pathogenesis of atopic dermatitis-like skin lesions in NC/Nga mice. NGF mediates its effects by binding to two classes of transmembrane receptors, a high-affinity receptor (tropomyosin-related kinase A, TrkA) and a low-affinity receptor (p75).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-0963
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17223862-Animals,
pubmed-meshheading:17223862-Carbazoles,
pubmed-meshheading:17223862-Dermatitis, Atopic,
pubmed-meshheading:17223862-Disease Models, Animal,
pubmed-meshheading:17223862-Drug Evaluation, Preclinical,
pubmed-meshheading:17223862-Enzyme Inhibitors,
pubmed-meshheading:17223862-Indole Alkaloids,
pubmed-meshheading:17223862-Male,
pubmed-meshheading:17223862-Mice,
pubmed-meshheading:17223862-Mice, Inbred Strains,
pubmed-meshheading:17223862-Pruritus,
pubmed-meshheading:17223862-Receptors, Nerve Growth Factor,
pubmed-meshheading:17223862-Treatment Outcome,
pubmed-meshheading:17223862-Tyrphostins
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model.
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pubmed:affiliation |
Pharmacological Evaluation Laboratory, Self Medication Laboratories, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama City, Saitama, Japan. n.takano@po.rd.taisho.co.jp
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pubmed:publicationType |
Journal Article
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