rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
1
|
pubmed:dateCreated |
2007-1-15
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pubmed:abstractText |
Recent studies showed high frequency of phosphatidylinositol 3-kinase catalytic alpha polypeptide (PIK3CA) mutations in various human cancers; notably, these mutations frequently locate in the hotspot mutation regions of PIK3CA exon 9 and exon 20 with functional significance in tumorigenesis, invasion, and anti-apoptosis. This study was to screen for mutations in the hotspot mutation regions of PIK3CA in nasopharyngeal carcinoma (NPC), and explore the correlation of PIK3CA mutations to tumorigenesis of NPC.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
1000-467X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
26
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17222361-Base Sequence,
pubmed-meshheading:17222361-Carcinoma, Squamous Cell,
pubmed-meshheading:17222361-Chromosomes, Human, Pair 22,
pubmed-meshheading:17222361-DNA, Neoplasm,
pubmed-meshheading:17222361-DNA Mutational Analysis,
pubmed-meshheading:17222361-Exons,
pubmed-meshheading:17222361-Female,
pubmed-meshheading:17222361-Humans,
pubmed-meshheading:17222361-Male,
pubmed-meshheading:17222361-Middle Aged,
pubmed-meshheading:17222361-Molecular Sequence Data,
pubmed-meshheading:17222361-Mutation,
pubmed-meshheading:17222361-Nasopharyngeal Neoplasms,
pubmed-meshheading:17222361-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:17222361-Polymerase Chain Reaction
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pubmed:year |
2007
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pubmed:articleTitle |
[Screening for mutations in the hotspot mutation regions of PIK3CA gene in nasopharyngeal carcinoma].
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pubmed:affiliation |
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|