This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
