| pubmed-article:17220306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0085508 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0017136 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:17220306 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:17220306 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17220306 | pubmed:dateCreated | 2007-3-22 | lld:pubmed |
| pubmed-article:17220306 | pubmed:abstractText | In this study we examined mechanisms that regulate T-helper lymphocyte 1 (Th1) commitment in Helicobacter pylori-infected human gastric mucosa. The levels of gamma interferon (IFN-gamma), interleukin-4 (IL-4), and IL-12 in total extracts of gastric biopsies taken from H. pylori-infected and uninfected patients were determined by an enzyme-linked immunosorbent assay. The levels of signal transducer and activator of transcription 4 (STAT4), STAT6, and T-box expressed in T cells (T-bet) in total proteins extracted from gastric biopsies were determined by Western blotting. Finally, the effect of a neutralizing IL-12 antibody on expression of Th1 transcription factors and the levels of IFN-gamma in organ cultures of H. pylori-infected biopsies was examined. Increased levels of IFN-gamma and IL-12 were found in gastric biopsy samples of H. pylori-infected patients compared to the levels in uninfected patients. In addition, H. pylori-infected biopsies exhibited high levels of expression of phosphorylated STAT4 and T-bet. Higher levels of IFN-gamma and expression of Th1 transcription factors were associated with greater infiltration of mononuclear cells in the gastric mucosa. By contrast, production of IL-4 and expression of phosphorylated STAT6 were not associated with the intensity of mononuclear cell infiltration. In ex vivo organ cultures of H. pylori-infected biopsies, neutralization of endogenous IL-12 down-regulated the expression of phosphorylated STAT4 and T-bet and reduced IFN-gamma production. Our data indicated that IL-12 contributes to the Th1 cell commitment in H. pylori-infected human gastric mucosa. | lld:pubmed |
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| pubmed-article:17220306 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17220306 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17220306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17220306 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17220306 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:17220306 | pubmed:author | pubmed-author:PalloneFrance... | lld:pubmed |
| pubmed-article:17220306 | pubmed:author | pubmed-author:LuzzaFrancesc... | lld:pubmed |
| pubmed-article:17220306 | pubmed:author | pubmed-author:ImeneoMariaM | lld:pubmed |
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| pubmed-article:17220306 | pubmed:author | pubmed-author:SebkovaLadisl... | lld:pubmed |
| pubmed-article:17220306 | pubmed:author | pubmed-author:PellicanòAnto... | lld:pubmed |
| pubmed-article:17220306 | pubmed:author | pubmed-author:GuarnieriGiov... | lld:pubmed |
| pubmed-article:17220306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17220306 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17220306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17220306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17220306 | pubmed:pagination | 1738-44 | lld:pubmed |
| pubmed-article:17220306 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17220306 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17220306 | pubmed:articleTitle | Interleukin-12 drives the Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa. | lld:pubmed |
| pubmed-article:17220306 | pubmed:affiliation | Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Campus Universitario di Germaneto, Viale Europa, 88100 Catanzaro, Italy. | lld:pubmed |
| pubmed-article:17220306 | pubmed:publicationType | Journal Article | lld:pubmed |
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