Source:http://linkedlifedata.com/resource/pubmed/id/17219172
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-2-5
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| pubmed:abstractText |
Patients with mitochondrial myopathy (MM) have a reduced capacity to perform exercise due to a reduced oxidative capacity. We undertook this study to determine whether skeletal muscle metabolism could be improved with oxygen therapy in patients with MM. Six patients with MM and six controls, matched for age, gender and physical activity, underwent (31)P-magnetic resonance spectroscopy ((31)P-MRS) examination. (31)P-MR spectra were collected at rest and in series during exercise and recovery whilst breathing normoxic (0.21 O(2)) or hyperoxic (1.0 O(2)) air. At rest, MM showed an elevated [ADP] (18 +/- 3 micromol/l) and pH (7.03 +/- 0.01) in comparison to the control group (12 +/- 1 micromol/l, 7.01 +/- 0.01) (P < 0.05) consistent with mitochondrial dysfunction. Oxygen supplementation did not change resting metabolites in either MM or the control group (P > 0.05). Inferred maximal ATP synthesis rate improved by 33% with oxygen in MM (21 +/- 3 vs. 28 +/- 5 mmol/(l min), P < 0.05) but only improved by 5% in controls (40 +/- 3 vs. 42 +/- 3 mmol/(l min), P > 0.05). We conclude that oxygen therapy is associated with significant improvements in muscle metabolism in patients with MM. These data suggest that patients with MM could benefit from therapies which improve the provision of oxygen.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1439-6319
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
99
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
541-7
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| pubmed:meshHeading |
pubmed-meshheading:17219172-Adenosine Diphosphate,
pubmed-meshheading:17219172-Adenosine Triphosphate,
pubmed-meshheading:17219172-Adult,
pubmed-meshheading:17219172-Exercise,
pubmed-meshheading:17219172-Female,
pubmed-meshheading:17219172-Humans,
pubmed-meshheading:17219172-Hydrogen-Ion Concentration,
pubmed-meshheading:17219172-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17219172-Male,
pubmed-meshheading:17219172-Middle Aged,
pubmed-meshheading:17219172-Mitochondria, Muscle,
pubmed-meshheading:17219172-Mitochondrial Myopathies,
pubmed-meshheading:17219172-Muscle, Skeletal,
pubmed-meshheading:17219172-Muscle Contraction,
pubmed-meshheading:17219172-Oxygen,
pubmed-meshheading:17219172-Oxygen Inhalation Therapy,
pubmed-meshheading:17219172-Phosphorus,
pubmed-meshheading:17219172-Recovery of Function,
pubmed-meshheading:17219172-Treatment Outcome
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients.
|
| pubmed:affiliation |
Department of Neurogenetics, Kolling Institute for Medical Research, Sydney, Australia. M.I.Trenell@ncl.ac.uk
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| pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|