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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-23
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pubmed:abstractText |
To investigate the importance of activation of the transcription factor, nuclear factor-kappaB (NF-kappaB) by interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) in the pathogenesis of osteoarthritis (OA) and assess its suitability as a target for therapy by determining its role in the induction of the cytokine IL-6 and the degenerative enzymes, matrix metalloproteinase (MMP)-1 and MMP-3 in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1462-0324
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
752-8
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pubmed:dateRevised |
2007-9-6
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pubmed:meshHeading |
pubmed-meshheading:17218328-Antirheumatic Agents,
pubmed-meshheading:17218328-Cells, Cultured,
pubmed-meshheading:17218328-Coculture Techniques,
pubmed-meshheading:17218328-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:17218328-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17218328-Humans,
pubmed-meshheading:17218328-Immunoglobulin G,
pubmed-meshheading:17218328-Interleukin-1beta,
pubmed-meshheading:17218328-Interleukin-6,
pubmed-meshheading:17218328-Matrix Metalloproteinase 1,
pubmed-meshheading:17218328-Matrix Metalloproteinase 3,
pubmed-meshheading:17218328-NF-kappa B,
pubmed-meshheading:17218328-Osteoarthritis,
pubmed-meshheading:17218328-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:17218328-Signal Transduction,
pubmed-meshheading:17218328-Synovial Membrane
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pubmed:year |
2007
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pubmed:articleTitle |
Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.
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pubmed:affiliation |
Rheumatology Research Laboratory, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. LauderSN@cardiff.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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