|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017725,
umls-concept:C0020538,
umls-concept:C0034705,
umls-concept:C0060291,
umls-concept:C0332161,
umls-concept:C0598783,
umls-concept:C0982374,
umls-concept:C1264633,
umls-concept:C1511903,
umls-concept:C1704419,
umls-concept:C1707455
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-1-12
|
|
pubmed:abstractText |
The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0.01 g/kg. Means and standard errors were calculated and the data were tested by one-way ANOVA followed by a least significance difference test. The results showed that both the DF and FA diets significantly improved hypertension as well as glucose tolerance, plasma nitric oxide (NOx), urinary 8-hydroxy-2'-deoxyguanosine and other parameters. In particular, compared to the FA diet, the DF diet produced a significant improvement in urinary NOx, hepatic triacylglycerol and several mRNA expressions of metabolic parameters involved in glucose and lipid metabolisms. The results of the metabolic syndrome-related parameters obtained from this study suggest that the DF diet is more effective than the FA diet.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Coumaric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoside Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/driselase,
http://linkedlifedata.com/resource/pubmed/chemical/ferulic acid
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0007-1145
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
97
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
67-76
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:17217561-Animals,
pubmed-meshheading:17217561-Antihypertensive Agents,
pubmed-meshheading:17217561-Biological Markers,
pubmed-meshheading:17217561-Blood Glucose,
pubmed-meshheading:17217561-Coumaric Acids,
pubmed-meshheading:17217561-Deoxyguanosine,
pubmed-meshheading:17217561-Dietary Fiber,
pubmed-meshheading:17217561-Fungal Proteins,
pubmed-meshheading:17217561-Glucose Tolerance Test,
pubmed-meshheading:17217561-Glycoside Hydrolases,
pubmed-meshheading:17217561-Hypertension,
pubmed-meshheading:17217561-Kidney,
pubmed-meshheading:17217561-Lipid Metabolism,
pubmed-meshheading:17217561-Liver,
pubmed-meshheading:17217561-Male,
pubmed-meshheading:17217561-Nitric Oxide,
pubmed-meshheading:17217561-Oryza sativa,
pubmed-meshheading:17217561-Peptidyl-Dipeptidase A,
pubmed-meshheading:17217561-RNA, Messenger,
pubmed-meshheading:17217561-Rats,
pubmed-meshheading:17217561-Rats, Inbred SHR,
pubmed-meshheading:17217561-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17217561-Stroke
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.
|
|
pubmed:affiliation |
Department of Science of Food Function and Health, Tohoku University, Japan. ardy@biochem.tohoku.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
