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| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0023824 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C1335280 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C1706044 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0201950 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C1418576 | lld:lifeskim |
| pubmed-article:17214991 | lifeskim:mentions | umls-concept:C0428466 | lld:lifeskim |
| pubmed-article:17214991 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17214991 | pubmed:dateCreated | 2007-10-9 | lld:pubmed |
| pubmed-article:17214991 | pubmed:abstractText | Insulin regulates apoB metabolism via activation of PI3K or regulation of MTP via MAPK/ERK signalling. SHP-2 enhances both pathways through increased IRS-1 phosphorylation. We hypothesized that variants in the SHP-2 gene PTPN11 and PI3K p85alpha subunit gene PIK3R1 may influence fasting levels of plasma apoB and/or LDL cholesterol. We tested association of tagging SNPs (tSNPs) in each gene with serum lipids in a large sample of unselected population-based Caucasian female twins (n=2771, mean age 47.4+/-12.5 years) and then tested interaction between tSNPs in determining apoB and LDL levels. PTPN11 tSNP rs11066322 was associated with apoB (P=0.007) and rs11066320 was associated with LDL cholesterol (P=0.016). PIK3R1 tSNP rs251406 was associated with apoB (P=0.0003) and rs706713 was associated with LDL cholesterol (P=0.009). PTPN11 tSNP rs11066322 interacted with PIK3R1 tSNP rs251406 in determining serum apoB levels (P=0.012) and with PIK3R1 tSNP rs40318 in determining LDL cholesterol levels (P=0.009). Association of single tSNPs with both apoB and LDL cholesterol as well as interactions between the two genes suggest that variants influencing SHP-2 activity may modulate the acute pathway by which insulin regulates these lipids. | lld:pubmed |
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| pubmed-article:17214991 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17214991 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17214991 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17214991 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17214991 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17214991 | pubmed:issn | 1879-1484 | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:SwaminathanRR | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:FryK LKL | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:SpectorT DTD | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:O'DellS DSD | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:SniederHH | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:JamshidiYY | lld:pubmed |
| pubmed-article:17214991 | pubmed:author | pubmed-author:GooljarS BSB | lld:pubmed |
| pubmed-article:17214991 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17214991 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:17214991 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17214991 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17214991 | pubmed:pagination | e26-33 | lld:pubmed |
| pubmed-article:17214991 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17214991 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17214991 | pubmed:articleTitle | SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. | lld:pubmed |
| pubmed-article:17214991 | pubmed:affiliation | Nutrition Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. | lld:pubmed |
| pubmed-article:17214991 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17214991 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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