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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0023824,
umls-concept:C0043210,
umls-concept:C0044602,
umls-concept:C0201950,
umls-concept:C0205307,
umls-concept:C0229671,
umls-concept:C0428466,
umls-concept:C1335280,
umls-concept:C1418576,
umls-concept:C1706044
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pubmed:issue |
2
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pubmed:dateCreated |
2007-10-9
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pubmed:abstractText |
Insulin regulates apoB metabolism via activation of PI3K or regulation of MTP via MAPK/ERK signalling. SHP-2 enhances both pathways through increased IRS-1 phosphorylation. We hypothesized that variants in the SHP-2 gene PTPN11 and PI3K p85alpha subunit gene PIK3R1 may influence fasting levels of plasma apoB and/or LDL cholesterol. We tested association of tagging SNPs (tSNPs) in each gene with serum lipids in a large sample of unselected population-based Caucasian female twins (n=2771, mean age 47.4+/-12.5 years) and then tested interaction between tSNPs in determining apoB and LDL levels. PTPN11 tSNP rs11066322 was associated with apoB (P=0.007) and rs11066320 was associated with LDL cholesterol (P=0.016). PIK3R1 tSNP rs251406 was associated with apoB (P=0.0003) and rs706713 was associated with LDL cholesterol (P=0.009). PTPN11 tSNP rs11066322 interacted with PIK3R1 tSNP rs251406 in determining serum apoB levels (P=0.012) and with PIK3R1 tSNP rs40318 in determining LDL cholesterol levels (P=0.009). Association of single tSNPs with both apoB and LDL cholesterol as well as interactions between the two genes suggest that variants influencing SHP-2 activity may modulate the acute pathway by which insulin regulates these lipids.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10332687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10421991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10579910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10762547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10842743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-10964160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-11397693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-11780939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12037407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12117729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12537873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12716735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12774165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12890923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-12890927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-14550627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-14574645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-14614235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-15226674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-15947244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-16249458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-16680028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-2187873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-4337382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-7658155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-7935386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-8063746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-8063747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-8647870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-9106493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-9246000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17214991-9388205
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e26-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17214991-Adult,
pubmed-meshheading:17214991-Apolipoproteins B,
pubmed-meshheading:17214991-Cholesterol, LDL,
pubmed-meshheading:17214991-Cohort Studies,
pubmed-meshheading:17214991-Female,
pubmed-meshheading:17214991-Genotype,
pubmed-meshheading:17214991-Humans,
pubmed-meshheading:17214991-Middle Aged,
pubmed-meshheading:17214991-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:17214991-Polymorphism, Single Nucleotide,
pubmed-meshheading:17214991-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:17214991-Twins
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pubmed:year |
2007
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pubmed:articleTitle |
SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women.
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pubmed:affiliation |
Nutrition Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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