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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-24
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pubmed:abstractText |
In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17213646-Animals,
pubmed-meshheading:17213646-Caspase 3,
pubmed-meshheading:17213646-Cells, Cultured,
pubmed-meshheading:17213646-Chemokine CXCL1,
pubmed-meshheading:17213646-Chemokines, CXC,
pubmed-meshheading:17213646-Colitis, Ulcerative,
pubmed-meshheading:17213646-Dextran Sulfate,
pubmed-meshheading:17213646-Disease Models, Animal,
pubmed-meshheading:17213646-Enzyme Activation,
pubmed-meshheading:17213646-Granzymes,
pubmed-meshheading:17213646-Lymphocytes,
pubmed-meshheading:17213646-Male,
pubmed-meshheading:17213646-Rats,
pubmed-meshheading:17213646-Rats, Sprague-Dawley,
pubmed-meshheading:17213646-Tryptases
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pubmed:year |
2007
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pubmed:articleTitle |
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
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pubmed:affiliation |
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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