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pubmed-article:17212615pubmed:abstractTextAn increased expression of adenine nucleotide translocator (ANT1), found in facioscapulohumeral muscular dystrophy (FSHD), is known to lead to a decrease in nuclear factor-kappaB (NF-kappaB) DNA binding and to sensitize muscle cells to oxidative stress and apoptosis. Receptor for advanced glycation end products (RAGE) mediated by NF-kappaB activation is involved in proinflammatory pathomechanism and in muscle fiber regeneration in inflammatory myopathies and in limb girdle muscular dystrophy. Oxidative stress can stimulate RAGE- NF-kappaB pathway. Our purpose was to verify if oxidative stress may induce RAGE- NF-kappaB pathway activation in FSHD, contributing to the pathogenesis of such a disease.lld:pubmed
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pubmed-article:17212615pubmed:articleTitleRAGE-NF-kappaB pathway activation in response to oxidative stress in facioscapulohumeral muscular dystrophy.lld:pubmed
pubmed-article:17212615pubmed:affiliationDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy. vmacaione@unime.itlld:pubmed
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