|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2007-1-10
|
|
pubmed:abstractText |
An increased expression of adenine nucleotide translocator (ANT1), found in facioscapulohumeral muscular dystrophy (FSHD), is known to lead to a decrease in nuclear factor-kappaB (NF-kappaB) DNA binding and to sensitize muscle cells to oxidative stress and apoptosis. Receptor for advanced glycation end products (RAGE) mediated by NF-kappaB activation is involved in proinflammatory pathomechanism and in muscle fiber regeneration in inflammatory myopathies and in limb girdle muscular dystrophy. Oxidative stress can stimulate RAGE- NF-kappaB pathway. Our purpose was to verify if oxidative stress may induce RAGE- NF-kappaB pathway activation in FSHD, contributing to the pathogenesis of such a disease.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0001-6314
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
115
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
115-21
|
|
pubmed:meshHeading |
pubmed-meshheading:17212615-Adenine Nucleotide Translocator 1,
pubmed-meshheading:17212615-Adolescent,
pubmed-meshheading:17212615-Adult,
pubmed-meshheading:17212615-Aged,
pubmed-meshheading:17212615-Case-Control Studies,
pubmed-meshheading:17212615-Child,
pubmed-meshheading:17212615-Child, Preschool,
pubmed-meshheading:17212615-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:17212615-Female,
pubmed-meshheading:17212615-Humans,
pubmed-meshheading:17212615-Male,
pubmed-meshheading:17212615-Middle Aged,
pubmed-meshheading:17212615-Muscle, Skeletal,
pubmed-meshheading:17212615-Muscular Dystrophy, Facioscapulohumeral,
pubmed-meshheading:17212615-NF-kappa B,
pubmed-meshheading:17212615-Oxidative Stress,
pubmed-meshheading:17212615-Receptors, Immunologic
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
RAGE-NF-kappaB pathway activation in response to oxidative stress in facioscapulohumeral muscular dystrophy.
|
|
pubmed:affiliation |
Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy. vmacaione@unime.it
|
|
pubmed:publicationType |
Journal Article
|
