Linked Life Data

1721164

Source:http://linkedlifedata.com/resource/pubmed/id/1721164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11 Pt 2
pubmed:dateCreated
1992-1-23
pubmed:abstractText
Guinea pig or rabbit atrial muscarinic K+ channels in cell-free inside-out patches can be activated in the absence of extracellular agonist and cytoplasmic G nucleotides by intracellular ATP-Mg2+. This ATP-dependent activation is compatible with the existence of a membrane-bound nucleoside diphosphate kinase (NDPK), which directly phosphorylates GK-bound GDP. We show that this ATP-dependent activation is also possible in frog atrial cells, and that atrial membranes of frog and guinea pig contain NDPK activity. The relative order of different nucleoside triphosphates (NTPs) as phosphate donors parallels the observed efficiency of these nucleotides in activation of the channels. Thus, atrial membranes contain NDPK activity, which can be responsible for the ATP-dependent activation of muscarinic K+ channels, seen in patches of atrial cells. Under physiological conditions, NDPK can act as a GTP supply in the immediate vicinity of the G protein to ensure reliable signal transduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0147-8389
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1721-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Atrial membranes contain nucleoside diphosphate kinase (NDPK) activity: its role in regulation of muscarinic K+ channels.
pubmed:affiliation
Department of Medicine, KU Leuven, Belgium.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't