Source:http://linkedlifedata.com/resource/pubmed/id/17211638
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-2-7
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| pubmed:databankReference | |
| pubmed:abstractText |
Intron 1 of the interferon-gamma (IFNG) gene contains two polymorphisms. The 12 CA-repeat allele of the +875 IFNGCA microsatellite and the T allele of the +A874T single nucleotide polymorphism (SNP) have been associated with increased in vitro IFNG production and a variety of clinical phenotypes. The purpose of this study was to determine whether these polymorphisms influence total serum IgE levels [tsIgE] and the outcome of a hepatitis B virus (HBV) infection. IFNGCA and +A874T were typed in 186 asthmatics of Niuean ancestry and in Polynesian women with a chronic HBV infection (n = 60) and with natural immunity to the HBV (n = 66). The IFNGCA genotype was associated with [tsIgE] in asthmatic children (n = 51, p = 0.004) but not adults (n = 135, p = 0.87). The data were consistent with a co-dominant influence of the 12 CA-repeat allele on high [tsIgE]. The IFNGCA genotype was also associated with the risk for chronic HBV infection (chi (2) = 11.6, p = 0.003) because of a dominant effect of the 12 CA-repeat allele on developing natural immunity in homozygotes (OR = 5.8, p = 0.003) and heterozygotes (OR = 2.7, p = 0.01). Similar associations were found for the T allele of the +A874T SNP. The possibility that these associations were due to linked alleles in the adjacent 783 bp of the promoter and 3'-untranslated region of the IFNG gene was excluded by direct sequencing. In summary, high-IFNG-producing alleles in intron 1 of the IFNG locus are associated with high [tsIgE] in asthmatic children from Niue and with natural immunity to the HBV in Polynesian women. These findings are consistent with a previous report of an association between +875 IFNGCA and [tsIgE] and provide preliminary evidence of a new association with the outcome of an HBV infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0093-7711
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
59
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
187-95
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17211638-Adolescent,
pubmed-meshheading:17211638-Adult,
pubmed-meshheading:17211638-Case-Control Studies,
pubmed-meshheading:17211638-Child,
pubmed-meshheading:17211638-Female,
pubmed-meshheading:17211638-Gene Frequency,
pubmed-meshheading:17211638-Genetic Predisposition to Disease,
pubmed-meshheading:17211638-Haplotypes,
pubmed-meshheading:17211638-Hepatitis B, Chronic,
pubmed-meshheading:17211638-Humans,
pubmed-meshheading:17211638-Immunoglobulin E,
pubmed-meshheading:17211638-Interferon-gamma,
pubmed-meshheading:17211638-Introns,
pubmed-meshheading:17211638-Male,
pubmed-meshheading:17211638-Microsatellite Repeats,
pubmed-meshheading:17211638-Molecular Sequence Data,
pubmed-meshheading:17211638-Polymorphism, Genetic,
pubmed-meshheading:17211638-Polynesia
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| pubmed:year |
2007
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| pubmed:articleTitle |
Polymorphism in intron 1 of the interferon-gamma gene influences both serum immunoglobulin E levels and the risk for chronic hepatitis B virus infection in Polynesians.
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| pubmed:affiliation |
New Zealand Liver Transplant Unit, Auckland City Hospital, Private Bag 92-024, Auckland, New Zealand. wghabbott@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|