|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-1-9
|
|
pubmed:abstractText |
In this study, we observed loss of heterozygosity (LOH) in human chromosomal fragment 6q25.1 in sporadic lung cancer patients. LOH was observed in 65% of the 26 lung tumors examined and was narrowed down to a 2.2-Mb region. Single-nucleotide polymorphism (SNP) analysis of genes located within this region identified a candidate gene, termed p34. This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine. Nearly 73% of heterozygous lung cancer tissues with LOH and the A/G SNP also exhibited loss of the A allele. In vitro clonogenic and in vivo nude mouse studies showed that overexpression of the A allele exerts tumor suppressor function compared with the G allele. p34 is located within a recently mapped human lung cancer susceptibility locus, and association of the p34 A/G SNP was tested among these families. No significant association between the less frequent G allele and lung cancer susceptibility was found. Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0008-5472
|
|
pubmed:author |
pubmed-author:AmosChristopher ICI,
pubmed-author:AndersonMarshall WMW,
pubmed-author:Bailey-WilsonJoan EJE,
pubmed-author:BierutLaura JLJ,
pubmed-author:FainPamela RPR,
pubmed-author:GabaColetteC,
pubmed-author:GazdarAdiA,
pubmed-author:GovindanRamaswamyR,
pubmed-author:JiaDongmeiD,
pubmed-author:KupertElenaE,
pubmed-author:LiuYanY,
pubmed-author:MandalDiptasriD,
pubmed-author:MinnaJohnJ,
pubmed-author:PetersenGloria MGM,
pubmed-author:PinneySusan MSM,
pubmed-author:RothschildHenryH,
pubmed-author:SchwartzAnn GAG,
pubmed-author:SeminaraDanielaD,
pubmed-author:VikisHaris GHG,
pubmed-author:ViswanathanAvinashA,
pubmed-author:WangDaolongD,
pubmed-author:WangYianY,
pubmed-author:WebbS LSL,
pubmed-author:WiestJonathan SJS,
pubmed-author:YangPingP,
pubmed-author:YouMingM,
pubmed-author:de AndradeMarizaM
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
67
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
93-9
|
|
pubmed:dateRevised |
2007-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:17210687-Alleles,
pubmed-meshheading:17210687-Animals,
pubmed-meshheading:17210687-Base Sequence,
pubmed-meshheading:17210687-Chromosomes, Human, Pair 6,
pubmed-meshheading:17210687-Codon,
pubmed-meshheading:17210687-Female,
pubmed-meshheading:17210687-Genes, Tumor Suppressor,
pubmed-meshheading:17210687-Genetic Predisposition to Disease,
pubmed-meshheading:17210687-Humans,
pubmed-meshheading:17210687-Loss of Heterozygosity,
pubmed-meshheading:17210687-Lung Neoplasms,
pubmed-meshheading:17210687-Mice,
pubmed-meshheading:17210687-Mice, Nude,
pubmed-meshheading:17210687-Molecular Sequence Data,
pubmed-meshheading:17210687-Polymorphism, Single Nucleotide
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
|
|
pubmed:affiliation |
School of Medicine, Washington University, 660 Euclid Avenue, St. Louis, MO, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
|
