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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
35
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pubmed:dateCreated |
1992-1-17
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M55199,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M55200,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M55201,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M74716,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M96682,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S66610,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S66768,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S70360,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S70364,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S70366,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S70399
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pubmed:abstractText |
Clones encoding an atypical beta-adrenergic receptor were isolated from a rat brown adipose tissue cDNA library. This receptor expressed in Chinese hamster ovary (CHO) cells displays a low affinity for beta-adrenergic antagonists and a high affinity for BRL 37344, an agonist that selectively stimulates lipolysis in adipose tissue. The rank order of potency for agonist-mediated increases in intracellular cAMP in transfected cells correlates with that for agonist-mediated stimulation of lipolysis in brown adipocytes. Northern blot analysis demonstrates that this receptor subtype is expressed only in brown and white adipose tissue where it represents the predominant beta-receptor subtype. The amount of atypical beta-adrenergic receptor present in adipose tissue of obese (fa/fa) Zucker rats is reduced by up to 71% as compared with lean (Fa/Fa) control animals. These findings suggest that a change in the expression of this beta-adrenergic receptor subtype may play a role in obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24053-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1721063-Adipose Tissue, Brown,
pubmed-meshheading:1721063-Adrenergic beta-Agonists,
pubmed-meshheading:1721063-Adrenergic beta-Antagonists,
pubmed-meshheading:1721063-Amino Acid Sequence,
pubmed-meshheading:1721063-Animals,
pubmed-meshheading:1721063-Base Sequence,
pubmed-meshheading:1721063-CHO Cells,
pubmed-meshheading:1721063-Cloning, Molecular,
pubmed-meshheading:1721063-Cricetinae,
pubmed-meshheading:1721063-DNA,
pubmed-meshheading:1721063-Down-Regulation,
pubmed-meshheading:1721063-Gene Library,
pubmed-meshheading:1721063-Humans,
pubmed-meshheading:1721063-Kinetics,
pubmed-meshheading:1721063-Male,
pubmed-meshheading:1721063-Molecular Sequence Data,
pubmed-meshheading:1721063-Obesity,
pubmed-meshheading:1721063-Poly A,
pubmed-meshheading:1721063-RNA,
pubmed-meshheading:1721063-RNA, Messenger,
pubmed-meshheading:1721063-Radioligand Assay,
pubmed-meshheading:1721063-Rats,
pubmed-meshheading:1721063-Rats, Inbred Strains,
pubmed-meshheading:1721063-Receptors, Adrenergic, beta,
pubmed-meshheading:1721063-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1721063-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity.
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pubmed:affiliation |
Departement de Biochimie Medicale, Centre Medical Universitaire, Geneve, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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