| pubmed-article:17208195 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:17208195 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:17208195 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17208195 | pubmed:dateCreated | 2007-2-26 | lld:pubmed |
| pubmed-article:17208195 | pubmed:abstractText | Chemokines are small (8-12 kDa) effector proteins that potentiate leukocyte chemonavigation. Beyond this role, certain chemokines have direct antimicrobial activity against human pathogenic organisms; such molecules are termed kinocidins. The current investigation was designed to explore the structure-activity basis for direct microbicidal activity of kinocidins. Amino acid sequence and 3-dimensional analyses demonstrated these molecules to contain iterations of the conserved gamma-core motif found in broad classes of classical antimicrobial peptides. Representative CXC, CC and C cysteine-motif-group kinocidins were tested for antimicrobial activity versus human pathogenic bacteria and fungi. Results demonstrate that these molecules exert direct antimicrobial activity in vitro, including antibacterial activity of native IL-8 and MCP-1, and microbicidal activity of native IL-8. To define molecular determinants governing its antimicrobial activities, the IL-8 gamma-core (IL-8gamma) and alpha-helical (IL-8alpha) motifs were compared to native IL-8 for antimicrobial efficacy in vitro. Microbicidal activity recapitulating that of native IL-8 localized to the autonomous IL-8alpha motif in vitro, and demonstrated durable microbicidal activity in human blood and blood matrices ex vivo. These results offer new insights into the modular architecture, context-related deployment and function, and evolution of host defense molecules containing gamma-core motifs and microbicidal helices associated with antimicrobial activity. | lld:pubmed |
| pubmed-article:17208195 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17208195 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17208195 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17208195 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17208195 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:YeamanMichael... | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:WaringAlan... | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:WelchWilliam... | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:GankKimberly... | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:YountNannette... | lld:pubmed |
| pubmed-article:17208195 | pubmed:author | pubmed-author:KupferwasserD... | lld:pubmed |
| pubmed-article:17208195 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17208195 | pubmed:volume | 1768 | lld:pubmed |
| pubmed-article:17208195 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17208195 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17208195 | pubmed:pagination | 598-608 | lld:pubmed |
| pubmed-article:17208195 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17208195 | pubmed:meshHeading | pubmed-meshheading:17208195... | lld:pubmed |
| pubmed-article:17208195 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17208195 | pubmed:articleTitle | Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidins. | lld:pubmed |
| pubmed-article:17208195 | pubmed:affiliation | Division of Infectious Diseases, LAC-Harbor UCLA Medical Center, Torrance, CA 90509, USA. | lld:pubmed |
| pubmed-article:17208195 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17208195 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17208195 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17208195 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17208195 | lld:pubmed |
