| pubmed-article:1720802 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1720802 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:1720802 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1720802 | pubmed:dateCreated | 1992-1-10 | lld:pubmed |
| pubmed-article:1720802 | pubmed:abstractText | Recombinant human granulocyte-colony stimulating factor (G-CSF) and recombinant human granulocyte/macrophage-colony stimulating factor (GM-CSF) stimulate neutrophil production from precursors in the marrow and enhance granulocyte functions in vitro. We studied the effects of G-CSF and GM-CSF on neutrophil superoxide production and secretion. G-CSF and GM-CSF alone stimulated neither superoxide production nor secretion, but both agents primed neutrophils for superoxide production stimulated by either N-formylmethionyl-leucyl-phenylalanine (FMLP) or ionomycin. Optimal priming occurred with G-CSF at 5.3 ng/ml for 20 minutes and for GM-CSF at 1 ng/ml for 60 minutes. Priming by GM-CSF was more readily inhibited by the tyrosine kinase inhibitor ST638 but was unaffected by staurosporine. Conversely, G-CSF priming was inhibited by staurosporine but not by ST638. Neither protein kinase C translocation nor increased protein kinase C activity, however, were observed after G-CSF/GM-CSF treatment. Priming by G-CSF and GM-CSF was sensitive to pertussis toxin, suggesting the involvement of guanine nucleotide-binding proteins (G-proteins). Neutrophils from three siblings with cyclic neutropenia were studied to observe the effects of G-CSF treatment on neutrophil function in vivo; sibling 1 and sibling 2 were treated with G-CSF for 6 months, but sibling 3 was not in the treatment group. Compared with neutrophils from normal donors, neutrophils from sibling 1 and sibling 2 were primed in vivo for superoxide release stimulated by either ionomycin or FMLP. Superoxide released by neutrophils from sibling 3 was similar to control cells.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1720802 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1720802 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1720802 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1720802 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1720802 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1720802 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1720802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1720802 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1720802 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1720802 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1720802 | pubmed:issn | 0022-2143 | lld:pubmed |
| pubmed-article:1720802 | pubmed:author | pubmed-author:BoxerL ALA | lld:pubmed |
| pubmed-article:1720802 | pubmed:author | pubmed-author:BalazovichK... | lld:pubmed |
| pubmed-article:1720802 | pubmed:author | pubmed-author:AlmeidaH IHI | lld:pubmed |
| pubmed-article:1720802 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1720802 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:1720802 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1720802 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1720802 | pubmed:pagination | 576-84 | lld:pubmed |
| pubmed-article:1720802 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1720802 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1720802 | pubmed:articleTitle | Recombinant human G-CSF and GM-CSF prime human neutrophils for superoxide production through different signal transduction mechanisms. | lld:pubmed |
| pubmed-article:1720802 | pubmed:affiliation | Department of Pediatrics, University of Michigan, Ann Arbor 48109-0684. | lld:pubmed |
| pubmed-article:1720802 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1720802 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1720802 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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