Linked Life Data

17207771

Source:http://linkedlifedata.com/resource/pubmed/id/17207771

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pubmed-article:17207771pubmed:abstractTextAn adipokine resistin, a small cysteine-rich protein, is one of the major risk factors of insulin resistance. In the present study, transiently resistin-expressing mice using adenovirus method showed an impaired glucose tolerance due to insulin resistance. We found that resistin-expressing mice exhibited impaired insulin secretory response to glucose. In addition, in vitro treatment with resistin for 1 day induced insulin resistance in pancreatic islets and impaired glucose-stimulated insulin secretion by elevating insulin release at basal glucose (2.8 mM) and suppressing insulin release at stimulatory glucose (8.3 mM). In addition, resistin inhibited insulin-induced phosphorylation of Akt in islets as well as other insulin target organs. Furthermore, resistin induced SOCS-3 expression in beta-cells. In conclusion, resistin induces insulin resistance in islet beta-cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion.lld:pubmed
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pubmed-article:17207771pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:17207771pubmed:articleTitleResistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release.lld:pubmed
pubmed-article:17207771pubmed:affiliationDivision of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329-0498, Japan. nakata@jichi.ac.jplld:pubmed
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