|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-1-17
|
|
pubmed:abstractText |
An adipokine resistin, a small cysteine-rich protein, is one of the major risk factors of insulin resistance. In the present study, transiently resistin-expressing mice using adenovirus method showed an impaired glucose tolerance due to insulin resistance. We found that resistin-expressing mice exhibited impaired insulin secretory response to glucose. In addition, in vitro treatment with resistin for 1 day induced insulin resistance in pancreatic islets and impaired glucose-stimulated insulin secretion by elevating insulin release at basal glucose (2.8 mM) and suppressing insulin release at stimulatory glucose (8.3 mM). In addition, resistin inhibited insulin-induced phosphorylation of Akt in islets as well as other insulin target organs. Furthermore, resistin induced SOCS-3 expression in beta-cells. In conclusion, resistin induces insulin resistance in islet beta-cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
353
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1046-51
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:17207771-Adenoviridae,
pubmed-meshheading:17207771-Animals,
pubmed-meshheading:17207771-Blood Glucose,
pubmed-meshheading:17207771-Blotting, Western,
pubmed-meshheading:17207771-Cell Line,
pubmed-meshheading:17207771-Genetic Vectors,
pubmed-meshheading:17207771-Glucose,
pubmed-meshheading:17207771-Glucose Tolerance Test,
pubmed-meshheading:17207771-Humans,
pubmed-meshheading:17207771-Insulin,
pubmed-meshheading:17207771-Insulin Resistance,
pubmed-meshheading:17207771-Islets of Langerhans,
pubmed-meshheading:17207771-Male,
pubmed-meshheading:17207771-Mice,
pubmed-meshheading:17207771-Mice, Inbred ICR,
pubmed-meshheading:17207771-Phosphorylation,
pubmed-meshheading:17207771-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17207771-Resistin,
pubmed-meshheading:17207771-Suppressor of Cytokine Signaling Proteins
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release.
|
|
pubmed:affiliation |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329-0498, Japan. nakata@jichi.ac.jp
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
