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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-8
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pubmed:abstractText |
The gamma-aminobutyric acid-A (GABA(A)) receptor and glutamate receptors are among the most important target sites for the behavioral effects of ethanol. However, data in the literature concerning the ethanol modulation of the GABA(A) and glutamate receptors have been controversial. The activity of the neuronal nicotinic acetylcholine (ACh) receptors (nAChRs) has recently been reported to be potently augmented by ethanol. The activation of nAChRs is also known to cause the release of various neurotransmitters including GABA and glutamate. Thus, ethanol potentiation of nAChRs is expected to stimulate the GABAergic and glutamatergic systems.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-99
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:17207106-2-Amino-5-phosphonovalerate,
pubmed-meshheading:17207106-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:17207106-Animals,
pubmed-meshheading:17207106-Cell Polarity,
pubmed-meshheading:17207106-Central Nervous System Depressants,
pubmed-meshheading:17207106-Cerebral Cortex,
pubmed-meshheading:17207106-Data Interpretation, Statistical,
pubmed-meshheading:17207106-Dose-Response Relationship, Drug,
pubmed-meshheading:17207106-Ethanol,
pubmed-meshheading:17207106-Excitatory Amino Acid Antagonists,
pubmed-meshheading:17207106-Excitatory Postsynaptic Potentials,
pubmed-meshheading:17207106-Female,
pubmed-meshheading:17207106-Neurons,
pubmed-meshheading:17207106-Patch-Clamp Techniques,
pubmed-meshheading:17207106-Pregnancy,
pubmed-meshheading:17207106-Rats,
pubmed-meshheading:17207106-Rats, Sprague-Dawley,
pubmed-meshheading:17207106-Synaptic Transmission
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons.
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pubmed:affiliation |
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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