Linked Life Data

1720667

Source:http://linkedlifedata.com/resource/pubmed/id/1720667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1992-1-16
pubmed:abstractText
The binding sites of the antibiotics pactamycin and celesticetin on the rRNAs of Escherichia coli ribosomes were investigated by a chemical footprinting procedure. Pactamycin protected residues G-693 and C-795 in 16S RNA which are located in an important functional region of the 30S subunit participating in initiation complex formation and ribosomal subunit interaction. Celesticetin altered the reactivities of 5 residues A-2058, A-2059, A-2062, A-2451 and G-2505 within the central loop of domain V of 23S RNA which has been implicated in peptidyltransferase activity. Inferences are drawn concerning the mode of action of the antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9084
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1145-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs.
pubmed:affiliation
Biostructural Chemistry, Aarhus University, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't