Source:http://linkedlifedata.com/resource/pubmed/id/17204934
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-1-5
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| pubmed:abstractText |
Peripheral neuropathy is the most frequent neurologic complication associated with human immunodeficiency virus (HIV) infection, yet its pathogenesis remains poorly understood. To study the mechanisms causing HIV-induced peripheral nervous system disease, we examined trigeminal ganglia obtained from simian immunodeficiency virus (SIV)-inoculated macaques. SIV-infected macaques developed multifocal trigeminal ganglionitis of varying severity characterized by multifocal mononuclear infiltrates, neuronophagia, and neuronal loss resembling reports of HIV-associated changes present in dorsal root ganglia. Neuronal density, measured by calculating the fractional area of trigeminal ganglia occupied by neurons, was significantly lower in SIV-infected macaques versus uninfected macaques (p = 0.001). To characterize the inflammatory cell population and measure productive viral infection in ganglia, trigeminal ganglia from SIV-infected macaques were immunostained for macrophage or cytotoxic lymphocyte markers and for SIV gp41. The extent of macrophage infiltration in trigeminal ganglia was inversely correlated with neuronal loss (p = 0.001), whereas cytotoxic lymphocyte infiltration was not associated with neuronal loss. These studies demonstrate that alterations in the somatosensory ganglia of SIV-infected macaques closely parallel those observed in HIV-infected individuals and show that study of SIV-infected macaques may help elucidate the pathophysiology of HIV-induced peripheral neuropathy.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Regulatory and Accessory...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0022-3069
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
66
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
26-34
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| pubmed:dateRevised |
2011-6-2
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| pubmed:meshHeading |
pubmed-meshheading:17204934-Animals,
pubmed-meshheading:17204934-Antigens, CD,
pubmed-meshheading:17204934-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:17204934-CD4 Lymphocyte Count,
pubmed-meshheading:17204934-Cell Count,
pubmed-meshheading:17204934-Central Nervous System,
pubmed-meshheading:17204934-Gene Expression Regulation, Viral,
pubmed-meshheading:17204934-Gene Products, gag,
pubmed-meshheading:17204934-Immunohistochemistry,
pubmed-meshheading:17204934-In Situ Hybridization,
pubmed-meshheading:17204934-Infection,
pubmed-meshheading:17204934-Macaca,
pubmed-meshheading:17204934-Microscopy, Confocal,
pubmed-meshheading:17204934-Peripheral Nervous System,
pubmed-meshheading:17204934-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17204934-Simian immunodeficiency virus,
pubmed-meshheading:17204934-Time Factors,
pubmed-meshheading:17204934-Trigeminal Ganglion,
pubmed-meshheading:17204934-Viral Load,
pubmed-meshheading:17204934-Viral Regulatory and Accessory Proteins
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| pubmed:year |
2007
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| pubmed:articleTitle |
Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia.
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| pubmed:affiliation |
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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