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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-1-9
|
| pubmed:abstractText |
Daily feeding of technical hexachlorocyclohexane (HCH) (0.5, 5, 25, 250, and 500 mg/kg diet/d) for a period of 360 d to male rats elicited a dose-dependent toxicity, while the dose of technical HCH (0.5 mg/kg diet/d) did not produce signs of intoxication, mortality, organ body weight ratio, enzymatic, and pathomorphological changes. Other doses (5, 25, 250, and 500 mg/kg diet/d) produced significant changes in one or the other parameters studied. Based on this study, it may be suggested that the lowest dose of technical HCH (0.5 mg/kg diet/d) could be considered as the no-observed-effect level in experimental rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0098-4108
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
495-507
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1720467-Administration, Oral,
pubmed-meshheading:1720467-Animal Feed,
pubmed-meshheading:1720467-Animals,
pubmed-meshheading:1720467-Body Weight,
pubmed-meshheading:1720467-Cerebellum,
pubmed-meshheading:1720467-Dose-Response Relationship, Drug,
pubmed-meshheading:1720467-Enzymes,
pubmed-meshheading:1720467-Kidney,
pubmed-meshheading:1720467-Lindane,
pubmed-meshheading:1720467-Liver,
pubmed-meshheading:1720467-Male,
pubmed-meshheading:1720467-Organ Size,
pubmed-meshheading:1720467-Rats,
pubmed-meshheading:1720467-Testis
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Long-term dietary study and development of no-observed-effect level (NOEL) of technical HCH to rats.
|
| pubmed:affiliation |
Pesticide Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
|
| pubmed:publicationType |
Journal Article
|