|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012472,
umls-concept:C0205263,
umls-concept:C0235032,
umls-concept:C0285890,
umls-concept:C0332281,
umls-concept:C0332621,
umls-concept:C0449560,
umls-concept:C0597357,
umls-concept:C0851285,
umls-concept:C1422733,
umls-concept:C1879547
|
|
pubmed:dateCreated |
2007-1-11
|
|
pubmed:abstractText |
The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute significantly to neurodegeneration in PD. It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-10617145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-10744035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-10873554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-10932230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-11454472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-11554012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-11591459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-11746782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-12385818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-12390510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-12539204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-12631585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-12834338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-1324050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-14607241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-14667941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-14756815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15350641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15390122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15639313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15668962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15728511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15790536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15791003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15793296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-15976091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16250904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16309709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16352863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16419087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16752909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-16823625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-6607092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-7891092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-8250933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-8858182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9239542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9313928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9482355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9732406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9754903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9930728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17204153-9930871
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/PTGER2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP2...,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Synuclein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1742-2094
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17204153-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:17204153-Animals,
pubmed-meshheading:17204153-Humans,
pubmed-meshheading:17204153-Lewy Body Disease,
pubmed-meshheading:17204153-Mice,
pubmed-meshheading:17204153-Mice, Inbred BALB C,
pubmed-meshheading:17204153-Mice, Knockout,
pubmed-meshheading:17204153-Microglia,
pubmed-meshheading:17204153-Receptors, Prostaglandin E,
pubmed-meshheading:17204153-Receptors, Prostaglandin E, EP2 Subtype,
pubmed-meshheading:17204153-alpha-Synuclein
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.
|
|
pubmed:affiliation |
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA. jinj@u.washington.edu <jinj@u.washington.edu>
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
