| pubmed-article:17202340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C1704240 | lld:lifeskim |
| pubmed-article:17202340 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:17202340 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17202340 | pubmed:dateCreated | 2007-1-4 | lld:pubmed |
| pubmed-article:17202340 | pubmed:abstractText | The impact of exposure to Ag on the development and maintenance of human CD4(+) memory T cells in general and HIV infection in particular is partially understood. In this study, we measured HIV-specific CD4(+) T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4(+) memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4(+) T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4(+) T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4(+) T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4(+) T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4(+) T cells. | lld:pubmed |
| pubmed-article:17202340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17202340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17202340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17202340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17202340 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17202340 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:RoutyJean-Pie... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:SekalyRafick-... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:TrautmannLydi... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:GrossmanZviZ | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:CameronThomas... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:SternLawrence... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:Yassine-DiabB... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:YounesSouheil... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:DumontAlain... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:KernaleguenAn... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:KalfayanLena... | lld:pubmed |
| pubmed-article:17202340 | pubmed:author | pubmed-author:BoulasselRach... | lld:pubmed |
| pubmed-article:17202340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17202340 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17202340 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:17202340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17202340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17202340 | pubmed:pagination | 788-97 | lld:pubmed |
| pubmed-article:17202340 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:17202340 | pubmed:meshHeading | pubmed-meshheading:17202340... | lld:pubmed |
| pubmed-article:17202340 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17202340 | pubmed:articleTitle | The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. | lld:pubmed |
| pubmed-article:17202340 | pubmed:affiliation | Laboratoire d'Immunologie, Département de Microbiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada. | lld:pubmed |
| pubmed-article:17202340 | pubmed:publicationType | Journal Article | lld:pubmed |
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