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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-4
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pubmed:abstractText |
The impact of exposure to Ag on the development and maintenance of human CD4(+) memory T cells in general and HIV infection in particular is partially understood. In this study, we measured HIV-specific CD4(+) T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4(+) memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4(+) T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4(+) T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4(+) T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4(+) T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4(+) T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BoulasselRachidR,
pubmed-author:CameronThomas OTO,
pubmed-author:DumontAlain RAR,
pubmed-author:GrossmanZviZ,
pubmed-author:KalfayanLena HLH,
pubmed-author:KernaleguenAnne-ElenAE,
pubmed-author:RoutyJean-PierreJP,
pubmed-author:SekalyRafick-PierreRP,
pubmed-author:SternLawrence JLJ,
pubmed-author:TrautmannLydieL,
pubmed-author:Yassine-DiabBaderB,
pubmed-author:YounesSouheil-AntoineSA
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
788-97
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17202340-Amino Acid Sequence,
pubmed-meshheading:17202340-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:17202340-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17202340-Cells, Cultured,
pubmed-meshheading:17202340-Conserved Sequence,
pubmed-meshheading:17202340-Gene Products, gag,
pubmed-meshheading:17202340-Gene Products, nef,
pubmed-meshheading:17202340-Gene Products, tat,
pubmed-meshheading:17202340-HIV Infections,
pubmed-meshheading:17202340-Humans,
pubmed-meshheading:17202340-Immunologic Memory,
pubmed-meshheading:17202340-Lymphocyte Count,
pubmed-meshheading:17202340-Molecular Sequence Data,
pubmed-meshheading:17202340-Substrate Specificity,
pubmed-meshheading:17202340-Time Factors,
pubmed-meshheading:17202340-nef Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:17202340-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2007
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pubmed:articleTitle |
The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells.
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pubmed:affiliation |
Laboratoire d'Immunologie, Département de Microbiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada.
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pubmed:publicationType |
Journal Article
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