Linked Life Data

17201995

Source:http://linkedlifedata.com/resource/pubmed/id/17201995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-10-31
pubmed:abstractText
Obtaining drugs for use in basic and preclinical research has become increasingly difficult and in many instances is dependent upon the company's interest in the proposed research. In this paper, we describe a simple procedure for extracting the antidepressants sertraline, paroxetine, fluoxetine, venlafaxine, citalopram, escitalopram, duloxetine and atomoxetine from their readily available pharmaceutical preparations. With the exception of citalopram, escitalopram and duloxetine in which the free base was the final product, the hydrochloride salt forms of these drugs were prepared. This procedure provides these antidepressants in gram quantities in recovered yields ranging from 53% to 100% at over 99% purity and is in principle applicable to other drugs as well.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1461-1457
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
759-63
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Preparation of antidepressants for use in preclinical research.
pubmed:affiliation
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural