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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-12-31
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pubmed:abstractText |
T cell immunity may be critical to development of a vaccine for human immunodeficiency virus (HIV-1). T helper epitopes were identified in three predominantly conserved regions in the HIV-1 reverse transcriptase by using reverse transcriptase-immunized mice of five major histocompatibility complex haplotypes. One peptide (residues 38-52) that stimulated H-2k T cells also contained an epitope recognized by cytotoxic T cells from the same mice and from HIV-infected patients. Such concordance between helper and cytotoxic T lymphocyte epitopes, observed in four cases, may be important in vaccine development. Peptide 36-52 was recognized by interleukin-2-producing peripheral blood T cells from 9 of 17 HIV-seropositive humans studied, of multiple human leukocyte antigen-DR and -DQ types. The broad recognition of this peptide by both helper and cytotoxic T cells substantiates its potential importance in a vaccine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:geneSymbol |
pol
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1058-65
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1720151-Adult,
pubmed-meshheading:1720151-Amino Acid Sequence,
pubmed-meshheading:1720151-Animals,
pubmed-meshheading:1720151-Dose-Response Relationship, Immunologic,
pubmed-meshheading:1720151-Epitopes,
pubmed-meshheading:1720151-Genes, pol,
pubmed-meshheading:1720151-HIV Antigens,
pubmed-meshheading:1720151-HIV Reverse Transcriptase,
pubmed-meshheading:1720151-HIV Seropositivity,
pubmed-meshheading:1720151-HIV-1,
pubmed-meshheading:1720151-HLA-DQ Antigens,
pubmed-meshheading:1720151-HLA-DR Antigens,
pubmed-meshheading:1720151-Haplotypes,
pubmed-meshheading:1720151-Humans,
pubmed-meshheading:1720151-Interleukin-2,
pubmed-meshheading:1720151-Lymphocyte Activation,
pubmed-meshheading:1720151-Major Histocompatibility Complex,
pubmed-meshheading:1720151-Mice,
pubmed-meshheading:1720151-Middle Aged,
pubmed-meshheading:1720151-Molecular Sequence Data,
pubmed-meshheading:1720151-RNA-Directed DNA Polymerase,
pubmed-meshheading:1720151-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1720151-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1991
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pubmed:articleTitle |
Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: correlation with a cytotoxic T cell epitope.
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pubmed:affiliation |
Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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