Source:http://linkedlifedata.com/resource/pubmed/id/17201119
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6B
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pubmed:dateCreated |
2007-1-4
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pubmed:abstractText |
JC virus (JCV) is a polyomavirus that causes progressive multifocal leukoencephalopathy (PML) in humans and is highly oncogenic in experimental animals. Transgenic mice with JCV T-antigen develop cerebellar tumors, which resemble human medulloblastomas, containing two distinct cell subpopulations, T-antigen positive and negative. In T-negative clones, a novel mutant p53 was detected (p53(mt)).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4079-92
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pubmed:meshHeading |
pubmed-meshheading:17201119-Animals,
pubmed-meshheading:17201119-Brain Neoplasms,
pubmed-meshheading:17201119-Cell Line, Tumor,
pubmed-meshheading:17201119-Flow Cytometry,
pubmed-meshheading:17201119-Humans,
pubmed-meshheading:17201119-Immunohistochemistry,
pubmed-meshheading:17201119-JC Virus,
pubmed-meshheading:17201119-Medulloblastoma,
pubmed-meshheading:17201119-Mice,
pubmed-meshheading:17201119-Mice, Transgenic,
pubmed-meshheading:17201119-Mutation,
pubmed-meshheading:17201119-Tumor Suppressor Protein p53
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pubmed:articleTitle |
Analysis of a mutant p53 protein arising in a medulloblastoma from a mouse transgenic for the JC virus early region.
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pubmed:affiliation |
Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19122, USA. martyn.white@temple.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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