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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-30
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pubmed:abstractText |
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:CampanMihaelaM,
pubmed-author:EgleDanielD,
pubmed-author:FieglHeidiH,
pubmed-author:JacobsIanI,
pubmed-author:LairdPeter WPW,
pubmed-author:MarthChristianC,
pubmed-author:Mueller-HolznerElisabethE,
pubmed-author:SpizzoGilbertG,
pubmed-author:WeisenbergerDaniel JDJ,
pubmed-author:WidschwendterMartinM,
pubmed-author:YoungJoanneJ
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-8
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17200673-Cell Differentiation,
pubmed-meshheading:17200673-Cell Transformation, Neoplastic,
pubmed-meshheading:17200673-DNA Methylation,
pubmed-meshheading:17200673-Epigenesis, Genetic,
pubmed-meshheading:17200673-Gene Silencing,
pubmed-meshheading:17200673-Humans,
pubmed-meshheading:17200673-Neoplasms,
pubmed-meshheading:17200673-Repressor Proteins,
pubmed-meshheading:17200673-Stem Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Epigenetic stem cell signature in cancer.
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pubmed:affiliation |
Department of Gynecological Oncology, Institute for Women's Health, University College London, London WC1E 6DH, UK. M.Widschwendter@ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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