| pubmed-article:17199039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C1155781 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:17199039 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17199039 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17199039 | pubmed:dateCreated | 2007-1-2 | lld:pubmed |
| pubmed-article:17199039 | pubmed:abstractText | Chromatin-induced spindle assembly depends on regulation of microtubule-depolymerizing proteins by the chromosomal passenger complex (CPC), consisting of Incenp, Survivin, Dasra (Borealin), and the kinase Aurora B, but the mechanism and significance of the spatial regulation of Aurora B activity remain unclear. Here, we show that the Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism. While spindle microtubule assembly normally requires Dasra-dependent chromatin binding of the CPC, this function of Dasra can be bypassed by clustering Aurora B-Incenp by using anti-Incenp antibodies, which stimulate autoactivation among bound complexes. However, such chromatin-independent Aurora B pathway activation promotes centrosomal microtubule assembly and produces aberrant achromosomal spindle-like structures. We propose that chromosomal enrichment of the CPC results in local kinase autoactivation, a mechanism that contributes to the spatial regulation of spindle assembly and possibly to other mitotic processes. | lld:pubmed |
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| pubmed-article:17199039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17199039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17199039 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17199039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17199039 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17199039 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:ChaitBrian... | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:KellyAlexande... | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:SampathSrinat... | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:FunabikiHiron... | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:WooEileen MEM | lld:pubmed |
| pubmed-article:17199039 | pubmed:author | pubmed-author:ManiarTapan... | lld:pubmed |
| pubmed-article:17199039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17199039 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:17199039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17199039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17199039 | pubmed:pagination | 31-43 | lld:pubmed |
