Linked Life Data

17198700

Source:http://linkedlifedata.com/resource/pubmed/id/17198700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Using microdialysis in rat prefrontal cortex, we found that 1 mg/kg of the stimulant methylphenidate and the non-stimulant atomoxetine, two widely used treatments for Attention Deficit/Hyperactivity Disorder (ADHD), produce robust increases in the extracellular levels of histamine, which plays a key role in attention, learning and memory. While the clinical response to ADHD drugs is typically attributed to modulation of norepinephrine and dopamine, this finding suggests enhanced histamine release may contribute to their efficacy as ADHD treatments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
558
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Methylphenidate and atomoxetine increase histamine release in rat prefrontal cortex.
pubmed:affiliation
Department of Neuroscience, MS 8220-4159, Pfizer Global Research and Development, Groton, CT 06340 USA.
pubmed:publicationType
Journal Article