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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2007-6-12
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pubmed:abstractText |
There is considerable evidence that genetic factors play an important role in the pathophysiology of affective disorders including bipolar disorder, major depressive disorder and anxiety disorders. Long-term follow up studies as well as drug treatment studies suggest that these clinical conditions share a number of pathophysiological commonalities including genetic variables. One possible candidate region is located on chromosome 12q24.31, originated from previous linkage and association studies with bipolar disorder and unipolar depression. This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-0327
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pubmed:author |
pubmed-author:BinderElisabeth BEB,
pubmed-author:ErhardtAngelikaA,
pubmed-author:HolsboerFlorianF,
pubmed-author:IsingMarcusM,
pubmed-author:KeckMartin EME,
pubmed-author:KernNikolaN,
pubmed-author:LiebRoselindR,
pubmed-author:LucaeSusanneS,
pubmed-author:Müller-MyhsokBertramB,
pubmed-author:SalyakinaDariaD,
pubmed-author:UhrManfredM,
pubmed-author:UnschuldPaul GPG
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-68
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17197037-Adult,
pubmed-meshheading:17197037-Agoraphobia,
pubmed-meshheading:17197037-Anxiety Disorders,
pubmed-meshheading:17197037-Calcium-Calmodulin-Dependent Protein Kinase Kinase,
pubmed-meshheading:17197037-Case-Control Studies,
pubmed-meshheading:17197037-Chromosomes, Human, Pair 12,
pubmed-meshheading:17197037-Female,
pubmed-meshheading:17197037-Genotype,
pubmed-meshheading:17197037-Haplotypes,
pubmed-meshheading:17197037-Humans,
pubmed-meshheading:17197037-Linkage Disequilibrium,
pubmed-meshheading:17197037-Male,
pubmed-meshheading:17197037-Middle Aged,
pubmed-meshheading:17197037-Panic Disorder,
pubmed-meshheading:17197037-Phenotype,
pubmed-meshheading:17197037-Phobic Disorders,
pubmed-meshheading:17197037-Polymorphism, Single Nucleotide,
pubmed-meshheading:17197037-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17197037-Receptors, Purinergic P2,
pubmed-meshheading:17197037-Receptors, Purinergic P2X7
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pubmed:year |
2007
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pubmed:articleTitle |
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
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pubmed:affiliation |
Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 München, Germany. erhardt@mpipsykl.mpg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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