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rdf:type |
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lifeskim:mentions |
umls-concept:C0011644,
umls-concept:C0016030,
umls-concept:C0026809,
umls-concept:C0037083,
umls-concept:C0040690,
umls-concept:C0205210,
umls-concept:C0205263,
umls-concept:C0205462,
umls-concept:C0205474,
umls-concept:C0443281,
umls-concept:C1710082,
umls-concept:C2348519
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-29
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pubmed:abstractText |
Increased signaling by transforming growth factor beta (TGFbeta) has been implicated in systemic sclerosis (SSc; scleroderma), a complex disorder of connective tissues characterized by excessive accumulation of collagen and other extracellular matrix components in systemic organs. To directly assess the effect of sustained TGFbeta signaling in SSc, we established a novel mouse model in which the TGFbeta signaling pathway is activated in fibroblasts postnatally.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxytamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein C Inhibitor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AdamsHenry PHP,
pubmed-author:BehringerRichard RRR,
pubmed-author:DengJenny MJM,
pubmed-author:DentonChristopher PCP,
pubmed-author:GengYong JYJ,
pubmed-author:HeRumingR,
pubmed-author:KeeneDouglas RDR,
pubmed-author:SonnylalSonaliS,
pubmed-author:VanpeltCarolyn SCS,
pubmed-author:ZhengBingB,
pubmed-author:de CrombruggheBenoitB
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
334-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17195237-Activin Receptors, Type I,
pubmed-meshheading:17195237-Animals,
pubmed-meshheading:17195237-Cell Differentiation,
pubmed-meshheading:17195237-Cells, Cultured,
pubmed-meshheading:17195237-Disease Models, Animal,
pubmed-meshheading:17195237-Female,
pubmed-meshheading:17195237-Fibroblasts,
pubmed-meshheading:17195237-Gene Targeting,
pubmed-meshheading:17195237-Male,
pubmed-meshheading:17195237-Mice,
pubmed-meshheading:17195237-Mice, Inbred C57BL,
pubmed-meshheading:17195237-Mice, Transgenic,
pubmed-meshheading:17195237-Phosphorylation,
pubmed-meshheading:17195237-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:17195237-Protein C Inhibitor,
pubmed-meshheading:17195237-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17195237-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:17195237-Scleroderma, Systemic,
pubmed-meshheading:17195237-Signal Transduction,
pubmed-meshheading:17195237-Skin,
pubmed-meshheading:17195237-Smad2 Protein,
pubmed-meshheading:17195237-Smad3 Protein,
pubmed-meshheading:17195237-Tamoxifen,
pubmed-meshheading:17195237-Transforming Growth Factor beta
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pubmed:year |
2007
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pubmed:articleTitle |
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.
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pubmed:affiliation |
University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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