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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-29
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pubmed:abstractText |
Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM). The purpose of this study was to investigate the ability of rAAV-mediated SOX9 overexpression to restore major ECM components in human OA articular cartilage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-67
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17195218-Adenoviridae,
pubmed-meshheading:17195218-Aged,
pubmed-meshheading:17195218-Cartilage, Articular,
pubmed-meshheading:17195218-Cell Proliferation,
pubmed-meshheading:17195218-Cells, Cultured,
pubmed-meshheading:17195218-Chondrocytes,
pubmed-meshheading:17195218-Collagen Type II,
pubmed-meshheading:17195218-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:17195218-Gene Dosage,
pubmed-meshheading:17195218-Gene Transfer Techniques,
pubmed-meshheading:17195218-Genetic Vectors,
pubmed-meshheading:17195218-High Mobility Group Proteins,
pubmed-meshheading:17195218-Humans,
pubmed-meshheading:17195218-Immunoenzyme Techniques,
pubmed-meshheading:17195218-Osteoarthritis, Knee,
pubmed-meshheading:17195218-Proteoglycans,
pubmed-meshheading:17195218-SOX9 Transcription Factor,
pubmed-meshheading:17195218-Tissue Culture Techniques,
pubmed-meshheading:17195218-Transcription Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9.
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pubmed:affiliation |
Saarland University Medical Center, Homburg, Germany. mmcucchiarini@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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