Linked Life Data

17194724

Source:http://linkedlifedata.com/resource/pubmed/id/17194724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-4-4
pubmed:abstractText
Acute stress affects gut functions through the activation of corticotropin-releasing factor (CRF) receptors. The impact of acute stress on pelvic viscera in the context of chronic stress is not well characterized. We investigated the colonic, urinary, and locomotor responses monitored as fecal pellet output (FPO), urine voiding, and ambulatory activity, respectively, in female and male CRF-overexpressing (CRF-OE) mice, a chronic stress model, and their wild-type littermates (WTL). Female CRF-OE mice, compared with WTL, had enhanced FPO to 2-min handling (150%) and 60-min novel environment (155%) but displayed a similar response to a 60-min partial restraint stress. Female CRF-OE mice, compared with WTL, also had a significantly increased number of urine spots (7.3 +/- 1.4 vs. 1.3 +/- 0.8 spots/h) and lower locomotor activity (246.8 +/- 47.8 vs. 388.2 +/- 31.9 entries/h) to a novel environment. Male CRF-OE mice and WTL both responded to a novel environment but failed to show differences between them in colonic and locomotor responses. Male WTL, compared with female WTL, had higher FPO (113%). In female CRF-OE mice, the CRF(1)/CRF(2) receptor antagonist astressin B and the selective CRF(2) receptor agonist mouse urocortin 2 (injected peripherally) prevented the enhanced defecation without affecting urine or locomotor responses to novel environment. RT-PCR showed that CRF(1) and CRF(2) receptors are expressed in the mouse colonic tissues. The data show that chronic stress, due to continuous central CRF overdrive, renders female CRF-OE mice to have enhanced pelvic and altered behavioral responses to superimposed mild stressors and that CRF(1)-initiated colonic response is counteracted by selective activation of CRF(2) receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1429-38
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17194724-Animals, pubmed-meshheading:17194724-Colon, pubmed-meshheading:17194724-Corticotropin-Releasing Hormone, pubmed-meshheading:17194724-Defecation, pubmed-meshheading:17194724-Environment, pubmed-meshheading:17194724-Female, pubmed-meshheading:17194724-Handling (Psychology), pubmed-meshheading:17194724-Injections, Subcutaneous, pubmed-meshheading:17194724-Male, pubmed-meshheading:17194724-Mice, pubmed-meshheading:17194724-Mice, Inbred C57BL, pubmed-meshheading:17194724-Motor Activity, pubmed-meshheading:17194724-Pelvis, pubmed-meshheading:17194724-Peptide Fragments, pubmed-meshheading:17194724-Receptors, Corticotropin-Releasing Hormone, pubmed-meshheading:17194724-Restraint, Physical, pubmed-meshheading:17194724-Stress, Psychological, pubmed-meshheading:17194724-Time Factors, pubmed-meshheading:17194724-Urination, pubmed-meshheading:17194724-Urocortins
pubmed:year
2007
pubmed:articleTitle
Enhanced pelvic responses to stressors in female CRF-overexpressing mice.
pubmed:affiliation
CURE: Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women's Health, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, CA 90073, USA. mmuluget@ucla.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural