Linked Life Data

17193319

Source:http://linkedlifedata.com/resource/pubmed/id/17193319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-12-28
pubmed:abstractText
This work lies within the framework of a broader project aimed at exploring the realm of all possible folded polypeptides; the main question addressed here is whether the corresponding RNAs also assume a folded conformation. We present an investigation on the structural properties of de novo, totally random RNAs by means of the 'RNA Foster' assay. Experimental results show that all RNAs studied are folded at 37 degrees , so that fold seems to be a common feature of RNAs. Random RNAs' fold shows a surprising thermal stability with an average T(m) value at ca. 50 degrees which prompts the idea that thermo-stable structures might not be as rare as they are commonly thought to be. The results are discussed within the general framework of random RNA properties such as those that might have been produced in a prebiotic scenario.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1612-1880
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
869-77
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Investigation of de novo totally random biosequences, Part IV: Folding Properties of de novo, totally random RNAs.
pubmed:affiliation
Department of Biology, University of Roma TRE, Viale G. Marconi 446, IT-00146 Rome.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't