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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-1-3
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pubmed:abstractText |
Normal aging is often associated with a decline in learning and memory functions. This decline is manifested to a much greater extent in Alzheimer's disease. Recent studies have indicated statins, a class of cholesterol-lowering drugs, as a potential therapy for Alzheimer's disease. Our objective was to determine whether administering a statin drug (simvastatin) would protect against the development of behavioral deficits in an established mouse model of Alzheimer's disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0364-5134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
729-39
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17192930-Alzheimer Disease,
pubmed-meshheading:17192930-Animals,
pubmed-meshheading:17192930-Anticholesteremic Agents,
pubmed-meshheading:17192930-Brain,
pubmed-meshheading:17192930-Cholesterol,
pubmed-meshheading:17192930-Cytoprotection,
pubmed-meshheading:17192930-Disease Models, Animal,
pubmed-meshheading:17192930-Female,
pubmed-meshheading:17192930-Learning,
pubmed-meshheading:17192930-Learning Disorders,
pubmed-meshheading:17192930-Memory,
pubmed-meshheading:17192930-Memory Disorders,
pubmed-meshheading:17192930-Mice,
pubmed-meshheading:17192930-Mice, Inbred C57BL,
pubmed-meshheading:17192930-Mice, Transgenic,
pubmed-meshheading:17192930-Neuroprotective Agents,
pubmed-meshheading:17192930-Nitric Oxide Synthase Type III,
pubmed-meshheading:17192930-Plaque, Amyloid,
pubmed-meshheading:17192930-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17192930-Signal Transduction,
pubmed-meshheading:17192930-Simvastatin,
pubmed-meshheading:17192930-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Simvastatin enhances learning and memory independent of amyloid load in mice.
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pubmed:affiliation |
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. lili@uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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