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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-12-13
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pubmed:abstractText |
Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0047-2565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-81
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1719205-Amino Acid Sequence,
pubmed-meshheading:1719205-Animals,
pubmed-meshheading:1719205-Antibodies, Viral,
pubmed-meshheading:1719205-B-Lymphocytes,
pubmed-meshheading:1719205-Dose-Response Relationship, Immunologic,
pubmed-meshheading:1719205-Epitopes,
pubmed-meshheading:1719205-Immune Sera,
pubmed-meshheading:1719205-Lymphocyte Activation,
pubmed-meshheading:1719205-Mice,
pubmed-meshheading:1719205-Mice, Inbred BALB C,
pubmed-meshheading:1719205-Molecular Sequence Data,
pubmed-meshheading:1719205-Neutralization Tests,
pubmed-meshheading:1719205-Retroviridae Proteins,
pubmed-meshheading:1719205-Retroviruses, Simian,
pubmed-meshheading:1719205-T-Lymphocytes,
pubmed-meshheading:1719205-Viral Envelope Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.
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pubmed:affiliation |
Oregon Regional Primate Research Center, Beaverton 97006.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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