Linked Life Data

17191834

Source:http://linkedlifedata.com/resource/pubmed/id/17191834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-28
pubmed:abstractText
The syntheses and olfactory evaluations of eight new macrocyclic musks with a 1,6-dioxa structure (1a-d and 1'a-d) as well as of twelve optically active 3-methyl macrolides (5a-c and 5'a-c) are reported. These macrocycles were synthesized via intramolecular metathesis mediated by the Grubbs catalyst. Despite the absence of a C=O function, the 1,6-dioxa compounds, both unsaturated (1) and saturated (1'), possess musky odors similar to those of macrocyclic ketones and lactones. Especially 16-membered rings were found to display an intense and pleasant musk character. However, in the case of optically active 3-methyl macrolides (5, 5'), only the (R)-configured 15- and 16-membered rings had intense and pleasant musk notes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1612-1880
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1985-91
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
New macrocyclic musk compounds.
pubmed:affiliation
Takasago International Corporation, Central Research Laboratory, 1-4-11 Nishi-yawata, Hiratsuka city, Kanagawa 254-0073, Japan. hiroyuki_matsuda@takasago.com
pubmed:publicationType
Journal Article