Linked Life Data

17190606

Source:http://linkedlifedata.com/resource/pubmed/id/17190606

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-12-27
pubmed:abstractText
The apposition of axon terminals and dendrites is critical for the control of neuronal activation, but how distinct neuronal subpopulations establish selective dendrite patterns and acquire specific presynaptic inputs remains unclear. Spinal motor neuron (MN) pools project to specific target muscles and are activated by selective synaptic inputs from group Ia proprioceptive afferents (IaPAs). Here, we show that MN pools with radially projecting dendrites respond to sensory stimulation with monosynaptic latency and are strikingly different from MN pools with dendrites that avoid the central gray matter, which are only activated through indirect connections. We provide genetic evidence that the induction of the ETS transcription factor Pea3 by GDNF is essential in two cervical MN pools to control dendrite patterning and selectivity of IaPA connectivity. These findings suggest that target-induced transcriptional programs control MN dendrite orientation and play a crucial role in the establishment of sensory-motor connections in the spinal cord.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1439-52
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3.
pubmed:affiliation
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't