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rdf:type |
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lifeskim:mentions |
umls-concept:C0008902,
umls-concept:C0022671,
umls-concept:C0031327,
umls-concept:C0050940,
umls-concept:C0085149,
umls-concept:C0205231,
umls-concept:C0332293,
umls-concept:C0376387,
umls-concept:C0376622,
umls-concept:C0744316,
umls-concept:C1332828,
umls-concept:C1457887,
umls-concept:C1556094,
umls-concept:C1882417
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pubmed:issue |
12
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pubmed:dateCreated |
2006-12-27
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pubmed:abstractText |
Lansoprazole and tacrolimus are substrates of ATP binding cassette (ABC) transporters such as P-glycoprotein (ABCBI/multidrug resistance 1) and cytochrome P450 (CYP). The purpose of this study was to investigate the implication of the ABCB1 C3435Tpolymorphism on the pharmacokinetics of (R)-lansoprazole, the major enantiomer, in CYP2C19 extensive metabolizers (EMs) and on gastroesophageal symptoms in renal transplant recipients receiving tacrolimus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Pyridinylmethylsulfinylbenzimidazo...,
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/lansoprazole
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0946-1965
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pubmed:author |
pubmed-author:HabuchiTT,
pubmed-author:InoueKK,
pubmed-author:IshikawaMM,
pubmed-author:KagayaHH,
pubmed-author:KannoSS,
pubmed-author:MiuraMM,
pubmed-author:SaitoMM,
pubmed-author:SatohSS,
pubmed-author:SuzukiTT,
pubmed-author:TABERE AEA,
pubmed-author:TadaHH
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-13
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17190370-2-Pyridinylmethylsulfinylbenzimidazoles,
pubmed-meshheading:17190370-Administration, Oral,
pubmed-meshheading:17190370-Adult,
pubmed-meshheading:17190370-Alleles,
pubmed-meshheading:17190370-Anti-Ulcer Agents,
pubmed-meshheading:17190370-Area Under Curve,
pubmed-meshheading:17190370-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:17190370-Asian Continental Ancestry Group,
pubmed-meshheading:17190370-Female,
pubmed-meshheading:17190370-Gastroesophageal Reflux,
pubmed-meshheading:17190370-Genotype,
pubmed-meshheading:17190370-Half-Life,
pubmed-meshheading:17190370-Humans,
pubmed-meshheading:17190370-Immunosuppressive Agents,
pubmed-meshheading:17190370-Japan,
pubmed-meshheading:17190370-Kidney Transplantation,
pubmed-meshheading:17190370-Male,
pubmed-meshheading:17190370-Middle Aged,
pubmed-meshheading:17190370-Mixed Function Oxygenases,
pubmed-meshheading:17190370-Organic Anion Transporters,
pubmed-meshheading:17190370-P-Glycoprotein,
pubmed-meshheading:17190370-Polymorphism, Genetic,
pubmed-meshheading:17190370-Tacrolimus
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pubmed:year |
2006
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pubmed:articleTitle |
Influence of ABCB1 C3435T polymorphism on the pharmacokinetics of lansoprazole and gastroesophageal symptoms in Japanese renal transplant recipients classified as CYP2C19 extensive metabolizers and treated with tacrolimus.
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pubmed:affiliation |
Department of Pharmaceutical Science, Akita University School of Medicine, Akita, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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