Linked Life Data

17190106

Source:http://linkedlifedata.com/resource/pubmed/id/17190106

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pubmed-article:17190106pubmed:abstractTextThe present study was designed to investigate the effect of aging and beta3-adrenergic-receptor (beta3-AR) polymorphism on the thermic effect of meal (TEM) and sympathetic nervous system (SNS) response to a high-fat meal in 13 boys, 12 young men, and 11 middle-aged men. SNS activity was assessed via power spectral analysis of heart rate variability. Significantly higher very-low-frequency (VLF) components associated with thermogenic SNS activity and energy expenditure per lean body mass (EE(LBM)) were observed in boys during the pre- and postprandial periods. There were no significant differences in VLF and EE(LBM) in the preprandial period between the young and middle-aged men. After feeding, however, the middle-aged men showed a significantly lower TEM (% test-meal energy) and VLF compared to the young men. A multiple regression analysis revealed that age was the only significant variable contributing to both TEM and VLF, but beta3-AR polymorphism and percentage of body fat were not statistically significant. In conclusion, age likely has a greater influence on TEM and SNS thermoregulation than genetic factors such as beta3-AR polymorphism, suggesting that this age-related decrease in thermogenic response may be involved in the development of obesity among middle-aged men.lld:pubmed
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pubmed-article:17190106pubmed:articleTitleImpact of aging and beta3-adrenergic-receptor polymorphism on thermic and sympathetic responses to a high-fat meal.lld:pubmed
pubmed-article:17190106pubmed:affiliationDepartment of Nutritional Science, Faculty of Health and Welfare, Okayama Prefectural University, Okayama 719-119 7, Japan.lld:pubmed
pubmed-article:17190106pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17190106pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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