Source:http://linkedlifedata.com/resource/pubmed/id/17190106
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2006-12-27
|
| pubmed:abstractText |
The present study was designed to investigate the effect of aging and beta3-adrenergic-receptor (beta3-AR) polymorphism on the thermic effect of meal (TEM) and sympathetic nervous system (SNS) response to a high-fat meal in 13 boys, 12 young men, and 11 middle-aged men. SNS activity was assessed via power spectral analysis of heart rate variability. Significantly higher very-low-frequency (VLF) components associated with thermogenic SNS activity and energy expenditure per lean body mass (EE(LBM)) were observed in boys during the pre- and postprandial periods. There were no significant differences in VLF and EE(LBM) in the preprandial period between the young and middle-aged men. After feeding, however, the middle-aged men showed a significantly lower TEM (% test-meal energy) and VLF compared to the young men. A multiple regression analysis revealed that age was the only significant variable contributing to both TEM and VLF, but beta3-AR polymorphism and percentage of body fat were not statistically significant. In conclusion, age likely has a greater influence on TEM and SNS thermoregulation than genetic factors such as beta3-AR polymorphism, suggesting that this age-related decrease in thermogenic response may be involved in the development of obesity among middle-aged men.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0301-4800
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
352-9
|
| pubmed:meshHeading |
pubmed-meshheading:17190106-Adult,
pubmed-meshheading:17190106-Age Factors,
pubmed-meshheading:17190106-Aging,
pubmed-meshheading:17190106-Analysis of Variance,
pubmed-meshheading:17190106-Child,
pubmed-meshheading:17190106-Dietary Fats,
pubmed-meshheading:17190106-Electrocardiography,
pubmed-meshheading:17190106-Energy Metabolism,
pubmed-meshheading:17190106-Female,
pubmed-meshheading:17190106-Food,
pubmed-meshheading:17190106-Heart Rate,
pubmed-meshheading:17190106-Humans,
pubmed-meshheading:17190106-Japan,
pubmed-meshheading:17190106-Male,
pubmed-meshheading:17190106-Middle Aged,
pubmed-meshheading:17190106-Monitoring, Physiologic,
pubmed-meshheading:17190106-Polymorphism, Genetic,
pubmed-meshheading:17190106-Postprandial Period,
pubmed-meshheading:17190106-Receptors, Adrenergic, beta-3,
pubmed-meshheading:17190106-Reference Values,
pubmed-meshheading:17190106-Sympathetic Nervous System,
pubmed-meshheading:17190106-Thermogenesis
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Impact of aging and beta3-adrenergic-receptor polymorphism on thermic and sympathetic responses to a high-fat meal.
|
| pubmed:affiliation |
Department of Nutritional Science, Faculty of Health and Welfare, Okayama Prefectural University, Okayama 719-119 7, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|